Gut Microbiota Modulation by High Fiber Diet Implications for Glucose Homeostasis and Inflammation in Type 2 Diabetes

James R. Fletcher; Emily K. Thompson; Daniel J. Carter; Sophie L. Harris

Authors

James R. Fletcher
Emily K. Thompson University of Liverpool, Faculty of Science and Engineering, School of Life Sciences, Liverpool, UK
Daniel J. Carter University of Liverpool, Faculty of Science and Engineering, School of Life Sciences, Liverpool, UK
Sophie L. Harris University of Manchester, Faculty of Biology, Medicine and Health, School of Biological Sciences, Manchester, UK

Keywords:

Gut microbiota, High-fiber diet, Diabetes management, Glucose balance, Metabolic regulation

Abstract

High-fiber diets have been widely studied for their benefits in managing type 2 diabetes (T2DM). However, the detailed molecular mechanisms by which they regulate glucose balance through gut microbiota remain unclear. This study uses metagenomic and metabolomic methods to examine the effects of a high-fiber diet on gut microbiota composition, short-chain fatty acid (SCFA) levels, and inflammation-related factors in a T2DM mouse model. Results show that a high-fiber diet improves glucose balance by increasing beneficial bacteria such as Bifidobacterium and Lactobacillus, which are linked to anti-inflammatory effects, while reducing harmful bacteria like Escherichia. These findings provide scientific evidence for the use of high-fiber diets in diabetes management and highlight their potential role in metabolic health.

Author Biography

James R. Fletcher

University of Liverpool, Faculty of Science and Engineering, School of Life Sciences, Liverpool, UK

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